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KMID : 0613820070170081152
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Journal of Life Science
2007 Volume.17 No. 8 p.1152 ~ p.1156
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Anti-Angiogenic and Anti-Cell Adhesion Effect of the Camellia japonica Flower Extract
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Heo In-Do
Seo Hyo-Jin
Kim Jong-Deog
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Abstract
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The Camella japonica flower(CJF) extract was studied for their anti-angiogenenic and anti-cell adhesion effect. CJF-extract inhibited the tube formation on human umbilical vein endotherial cells(HUVEC) with butanol extract by 70.2%, acetone extract by 54.2%, ethyl acetate extract by 37.0%, chloroform extract by 21.2%. Cell adhesion molecules were effectively suppressed at different concentration of CJF at 50, 100, 200 ㎍ /well such as for intercellular adhesion molecule(ICAM) by 5.9%, 29.4% and 52.9%, for vascular cell adhesion molecule(VCAM) by 12.5%, 43.8% and 62.5%, for E-selectin by 7.1%, 21.4% and 35.7%, respectively. Signal molecules of vascular endotherial growth factor receptor 2(VEGFR2), β-catenin and PI3K are inhibited by different concentration of CJF at 10, 20 and 30 ㎍/mL with western blot. Angiogenesis will be inhibited with suppressing NF-kB molecule resulted in signal molecules blocked by CJF. CJF will be useful materials for treatment of angiogenesis related diseases such as cancer, metastasis, rheumathioid arthritis and obesity.
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KEYWORD
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Camellia japonica flower, angiogenesis, cell adhesion, NF-kB, anti-cancer, anti-obesity
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